Description
MOTS-c – 40 MG
Research Overview
MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide encoded within mitochondrial DNA. It has been investigated for its role in cellular metabolic signalling and communication between mitochondria and the nucleus.
Research Focus
Research involving MOTS-c has examined metabolic homeostasis, glucose metabolism, insulin sensitivity, energy regulation and skeletal muscle function. Preclinical studies have investigated MOTS-c in relation to the AMPK signalling pathway, which is involved in cellular energy sensing and metabolic regulation.
Metabolic & Exercise Research
MOTS-c has also been investigated in exercise-related research. Studies have reported that exercise can influence endogenous MOTS-c expression, while experimental research has examined its relationship with skeletal muscle metabolism, physical capacity and adaptation to metabolic stress. Findings involving enhanced physical performance have primarily been demonstrated in animal models.
Scientific Context
Current research suggests that MOTS-c may participate in mitochondrial-to-nuclear signalling and cellular responses to metabolic stress. Proposed mechanisms include interactions with the folate-methionine cycle, AICAR production and downstream AMPK signalling. However, the biological effects of MOTS-c can vary according to experimental model and research conditions.
Important Research Note
Much of the evidence surrounding MOTS-c remains preclinical, with substantial research conducted in cellular and animal models. Human research has also examined circulating MOTS-c and exercise-related expression, but these studies do not establish MOTS-c as an approved therapeutic treatment or demonstrate established clinical efficacy.
This product is supplied for laboratory and scientific research purposes only and is not intended for human or veterinary use, diagnosis, treatment, or prevention of any disease or condition.
For research purposes only. Not intended for human or veterinary use.
